Equine Herpesvirus Type 1–Associated Myeloencephalopathy In The Netherlands: A Four-Year Retrospective Study (1999–2003)

Goehring, Lutz S.; van Winden, Steven C.; van Maanen, C.; Sloet van Oldruitenborgh-Oosterbaan, Marianne M.

doi:10.1892/0891-6640(2006)20[601:ehtami]2.0.co;2

Cited by 123Herpesvirus Infections and TreatmentsAnimal Virus Infections StudiesVeterinary Equine Medical Research

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Equine Herpesvirus Type 1–Associated Myeloencephalopathy In The Netherlands: A Four-Year Retrospective Study (1999–2003)

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Goehring, Lutz S., van Winden, Steven C., van Maanen, C., Sloet van Oldruitenborgh-Oosterbaan, Marianne M.·2006·Journal of Veterinary Internal Medicine

DOI 10.1892/0891-6640(2006)20[601:ehtami]2.0.co;2

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Abstract

Equine herpesvirus type 1(EHV-1)-associated myeloencephalopathy (EHM) is a rare disease affecting the central nervous system and, in particular, the spinal cord of horses. Epidemiologic data are limited, and usually are restricted to the description of a single outbreak. During an observational period of 4 years, we evaluated 9 outbreaks of EHM in The Netherlands. A risk factor analysis was done on the data from 6 outbreaks. Findings were: regular appearance of EHM outbreaks in The Netherlands (2-3/y); strong association of EHM with season; and risk factors, such as breed, sex, age, and fever. Female horses, aged horses, and specific breeds were at greater risk to develop severe neurologic disease. Other breeds and horses <3 years old were never observed to suffer from EHM during these outbreaks. It was concluded that breed variation, in addition to the presence of a specific EHV-1 strain, and environmental factors influence an outbreak of EHM on a premise.

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Pollen concentrations in outdoor air peak between late winter and spring, a period that coincides with high incidence of seasonally observed EHV-1-associated symptoms.
“Interestingly, pollen concentrations in the outdoor air have been shown to peak between late winter and spring, a period that coincides with high incidence of seasonally observed EHV-1-associated symptoms (e.g., respiratory disease, abortion and EHM) (Goehring et al., 2006; D’Amato et al., 2007).”
From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Goehring et al., 2006
Several risk factors, including older age, Standardbred breed, female gender, late autumn/winter/spring season, and neurovirulent EHV-1 strain, have been associated with an increased risk to develop equine herpes myeloencephalopathy.
“Several risks factors, including the age (elder), breed (Standardbred), gender (female), season (late autumn, winter, spring), and type of EHV-1 strain (neurovirulent) have been associated with an increased risk to develop EHM (Goehring et al., 2006; Henninger et al., 2007; Allen, 2008; Perkins et al., 2009; Pusterla et al., 2016).”
From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Goehring et al., 2006

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A retrospective study on equine herpesvirus type-1 associated myeloencephalopathy in France (2008–2011)
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A Retrospective Study on Equine Herpesvirus‐1 Associated Myeloencephalopathy in F rance (2008–2011)
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Authors: Goehring, L. S., van Winden, S. C., van Maanen, C., & Sloet van Oldruitenborgh-Oosterbaan, M. M.
Affiliations: Utrecht University (NL)
Royal Veterinary College (GB)
De Gezondheidsdienst voor Dieren (NL)
Corresponding author: Goehring, Lutz S.
ORCID: Goehring, Lutz S.
Venue: Journal of Veterinary Internal Medicine
Publisher: Oxford University Press (OUP)
Published: 2006
Volume: 20
Issue: 3
Pages: 601
ISSN: 0891-6640 (ISSN-L)
DOI: 10.1892/0891-6640(2006)20[601:ehtami]2.0.co;2
OpenAlex: W2023498118
Cited by: 123
References: 29
Citations by year: 2026: 3 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 11 · 2021: 10 · 2020: 5 · 2019: 10 · 2018: 8 · 2017: 5 · 2016: 1 · 2015: 6 · 2014: 5 · 2013: 8 · 2012: 7
FWCI: 4.17
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: doi.wiley.com/10.1002/tdm_license_1 (tdm, 3530 d)
Locations: Journal of Veterinary Internal Medicine (publishedVersion)
PubMed (publishedVersion)
RVC Research Online (Royal Veterinary College) (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Health Sciences › Veterinary › Equine › Veterinary Equine Medical Research
Keywords: equine herpesvirus 1, myeloencephalopathy, horses, outbreak epidemiology, risk factors, breed predisposition, seasonal variation, neurological disorders, fever, environmental factors
MeSH terms: Animals, Disease Outbreaks, Encephalomyelitis, Herpesvirus 1, Equid, Female, Herpesviridae Infections, Horse Diseases, Horses, Male, Netherlands, Pedigree, Records, Retrospective Studies, Risk Factors

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Equine Herpesvirus Type 1–Associated Myeloencephalopathy In The Netherlands: A Four-Year Retrospective Study (1999–2003)

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